This drug poses an elevated possibility of compromised means to keep up hypertension because of peripheral vasodilation as well as other mechanisms Label. Consequences on Long-term most cancers soreness and other kinds of pain
Tend not to use with any other drug made up of acetaminophen with out inquiring your medical professional or pharmacist 1st. Acetaminophen is in many nonprescription and prescription medicines (such as agony/fever drugs or cough-and-cold products and solutions).
Gut Blockage. Promethazine/phenylephrine/codeine should not be utilized In case you have a blockage of your respective gut (bowel obstruction) or maybe a narrowing on the stomach or intestines. Promethazine/phenylephrine/codeine can make these disorders worse.
Codeine has actually been described to point out no evidence of carcinogenicity or mutagenicity in many different examination devices, such as the micronucleus and sperm abnormality assays along with the Salmonella assay. Promethazine was nonmutagenic from the Salmonella exam program of Ames.
22 A urine sample confirmed greater metabolite concentrations. Genotyping of CYP2D6 was carried out, and a few useful alleles were discovered which were according to ultra-swift metabolism.
Prior to deciding to have any health care exams, inform the clinical health care provider in charge you or your son or daughter are using this medication. The outcomes of some tests may be influenced by this drugs.
Inside our critique on the healthcare literature1-19 for info relating to codeine use throughout breastfeeding, we uncovered numerous cases of excessive sleepiness and really serious breathing difficulties in breastfed infants, such as one particular Demise.
Promethazine/phenylephrine/codeine can have an effect on your alertness or coordination. Do not generate or do other actions that demand alertness or coordination until you understand how the medicine has an effect on you.
Bone-Marrow Despair – Promethazine should be used with warning in individuals with bone-marrow despair. Leukopenia and agranulocytosis have been described, typically when promethazine HCl continues to be Utilized in association with other recognized marrow-toxic brokers.
Amplified prescribing of opioids and antidepressants suggests a lot more clients are taking medicine from Every single course. But some mixtures Have a very higher possibility of toxicity.
Breathing Difficulties. Promethazine/phenylephrine/codeine may perhaps induce sluggish or shallow respiratory, especially if you've respiration challenges from another ailment or take other medicines that can gradual your respiratory.
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This medicine may trigger many people to become dizzy, drowsy, or much less alert than They're Usually. Don't travel or do anything that can be hazardous till you know the way this medication affects you.
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